Check out today’s Step 1 Qmax Question Challenge.
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A 2-year-old child has required frequent transfusions throughout his life because of anemia. A peripheral blood smear demonstrates microcytic, hypochromic red cells, with target cells and anisopoikilocytosis. After further genetic testing, the child’s spleen is removed to lessen the need for transfusions. When the suspected causal RNA is amplified and sequenced, the mutation in the image is seen at the 5′ end of one of his introns.
This change is most likely to affect which of the following processes?
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