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A 10-year-old boy is brought to the emergency department after falling from his bicycle. He presents with a large, painfully swollen knee; aspiration shows gross hemarthrosis. On further questioning, the patient’s parents say that he bruises easily and that it took several days for the bleeding to completely stop after losing a tooth 1 month ago. His maternal uncle had similar bleeding difficulties. After further testing, the patient is diagnosed with an X-linked recessive disorder.
Which of the following laboratory test results corresponds to the patient’s disorder?
A. A
B. B
C. C
D. D
E. E
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C. Hemophilia
IT IS A OPTION BECAUSE it occurs in the hemophilia
A. Hemophilia
A
It’s A. Hemophilia results in these labs PT is normal, PTT is abnormal and bleeding time is normal.
C
A)
Hemophilia with Factor VIII (Antihaemophilic Factor) deficiency which is a component of Intrinsic Pathway of Coagulation which in turn is monitored by aPTT.
It does not affect platelets, BT and Extrinsic Pathway of Coagulation.
Correction,
A is the correct answer . Bleeding time normal.
A
a
Hemophlia
A, because bleeding time is normal in hemophilia (platelet function is intact), prothrombin time (PT) is normal in hemophilia (because of extrinsic factor, especially FVII, is normal in hemophilia – not in vitamin K deficiency or under warfarin treatment) and partial thromboplastin time (PTT) is extended since PTT involves all clotting factors (so including the ones involved in hemophilia) except FVII and FXIII.
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