USMLE-Rx Step 1 Qmax Challenge #1379

Check out today’s Step 1 Qmax Question Challenge.

Know the answer? Post it below! Don’t forget to check back for an update with the correct answer and explanation (we’ll post it in the comments section below).

usmle-rx-step-1-qmax-challenge-1379A 31-year-old man comes to a gastroenterologist for a complete work-up after experiencing bouts of unexplained rectal bleeding, pain in his abdomen, and diarrhea. A flexible sigmoidoscopy is performed, and the result is shown in the image below on the left. The patient is counseled that his son and daughter must also be evaluated in the future.

The patient was lost to follow-up but returns to clinic 5 years later with similar, yet more severe symptoms. The patient undergoes another sigmoidoscopy and a biopsy specimen is obtained, which is found to be malignant.

Which of the gene pairs in the table above are most likely representative of the mutations present in this patient’s tumor?

A. A
B. B
C. C
D. D
E. E


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9 thoughts on “USMLE-Rx Step 1 Qmax Challenge #1379”

  1. A
    This question had been posted earlier much earlier but can’t remember the exact time interval.
    Repeat Question

    Though APC,P53 are not oncogenes which rules out B/C/D & BCR-ABL is associated with CML not CRC which excludes E

  2. Correct answer is A
    .Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling pathway is very frequent in colorectal cancer and is associated with poor prognosis.

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