Rx Bricks Podcast: Gastrointestinal Regulatory Substances

Gastrointestinal Regulatory Substances

As we eat, our gastrointestinal (GI) system releases a host of both local and distant gastrointestinal regulatory substances to control the process of digestion. We will begin with the primary hormones, then cover some of the secondary hormones, and lastly discuss how our body senses its intraluminal contents and then subsequently integrates all of the various stimuli it receives.

After listening to this AudioBrick, you should be able to:

  • Identify the location, cell type, release stimulus to the endocrine cells, and function of the major gastrointestinal (GI) hormones secretin, cholecystokinin (CCK), gastrin, vasoactive intestinal polypeptide (VIP).
  • Describe in brief the release stimulus and function of the GI regulatory peptides bombesin, GLP-1, GLP-2, ghrelin, leptin, motilin, somatostatin, and gastric inhibitory polypeptide (GIP).
  • Understand how the physical and chemical compositions of luminal contents are sensed and the hormonal responses that then occur.
  • Outline how GI cells integrate multiple regulatory inputs from hormonal and neural inputs to control function.

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