This week’s edition of the Step 1 Question of the Week is about GI Physiology. See if you can answer the question and then watch the video to learn the correct answer as well as the rationales for each option.
GI Physiology
A 25-year-old man with refractory schizophrenia begins taking clozapine. At a 1-month follow-up visit, his serum clozapine is at a therapeutic level, but he says he has pain in both of his cheeks right in front of his ears, as well as pain when he swallows. On further questioning, he also says he has produced more saliva lately than usual. On examination, he is found to be afebrile.
In the setting of the increased saliva flow rate in this patient, which of the following substances will show a decreased salivary concentration, compared with the findings before taking clozapine?
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