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A 22-year-old man visits his primary care physician after recently being discharged from the hospital. Before hospitalization, the patient presented with 1 day of nausea, vomiting, and abdominal pain radiating to his back. He denies smoking, alcohol use, or illicit drug use. He reports that his maternal grandfather died from colon cancer at the age of 76. Other than the recent hospitalization, his medical history is significant only for uncontrolled diabetes.
Relevant labs from the hospital:
Triglycerides: >1000 mg/dL
Lipase: 714 U/L
Imaging from his hospitalization is shown.
Repeated labs today:
LDL: 124 mg/dL
HDL: 48 mg/dL
Triglycerides: 644 mg/dL
What is the mechanism of action of the first-line pharmaceutical intervention indicated for this patient?
A. Increases activity of lipoprotein lipase
B. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase
C. Inhibits intestinal absorption of cholesterol
D. Inhibits lipolysis by hormone-sensitive lipase
E. Sequestration of charged bile acids
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